Curious - why was testing only done on the male pups? Carrier status only matters for breeding,
a carrier is just as healthy as a clear littermate and will not develop this disease or suffer any consequences as a result (as far as we know at this time). From the OptiGen website:
Our current understanding is that CMR is inherited in an autosomal recessive pattern. This means the gene mutation responsible for CMR is located on an autosome (that is, a chromosome that is not a sex chromosome) and CMR disease results when the gene mutation is passed to the offspring by both the mother and the father.
The benefits of genetic disease testing are clear. With informed breeding practices, breeders immediately can avoid producing CMR affected pups, yet use any healthy dog in their program regardless of genetic status. And since genetic testing can be done at any age, each dog’s genetic status can be known even before clinical disease signs are recognized. Over several generations of selection away from the disease gene, breeders can eliminate a disease gene completely from their line.
Bold emphasis added by myself. And the mention of genetic status includes affecteds - an affected CMR dog mated w/ a clear dog will produce a litter of all carriers, but none of the pups will develop the disease or have any health issues associated with 1 copy of the disease gene (again, as far as we know at this time)
Not sure if you already knew this, but I guess just more information for anyone who does not understand autosomal-recessive genes. I guess I just don't understand the sad/crying face about the pup who is a carrier. He has every potential to be just as healthy as yours and can still be used as a stud as long as he is only used on CMR clear females if that's the owners intent/hope. Males have so many other barriers to overcome before they are even considered to be used at stud for responsible bitch owners, CMR carrier is not always a deterrant for owners of
clear females
if they like everything else about the male. Not every breeder will agree, but many responsible ones have no issue with using a CMR carrier (or even affected) dog in their program because the KNOW they can ensure no pups will acquire the disease if they use the tools given to them correctly.
I was hoping they would both be clear but very happy he isnt a carrier!!!!
